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泛球生物--发酵菌种--工艺技术--产业化推广

ABOUT US:

Gbio, depending on the science and technology platform of China Academy of Sciences, Tsinghua University , Peking University and so on, devotes to consultation, technology transfer, patent licensing, technology development, technology incubation, engineering, commissioning and training in biological science and biotechnology, and explores actively new models of commercialization of new technology from lab to industry. Gbio owns R&D group of specialist and professor from famous university and institute, engineering group of experienced engineers from the industry, and marketing group of international partners. GLbio’s technology is very competitive in the world.

Additionally Gbio owns the pilot base and guarantee the transferred technology at least is pilot stage, then is given to the industry. Gbio also owns HPLC, UV, PCR, automatic fermenter and other laboratory equipments. We not only make and supply products, but also provide fermentation related technology to our clients in fine chemical and pharmaceutical industries. From R&D to production, from analytical to QC, we are ready to serve customers' needs. With strong technical and regulatory expertise, we are looking forward to entering long-term partnership with more clients worldwide.

OUR SERVICES:

PRODUCT, TECHNOLOGY and CONSULTING

CONSULTING

• Market Research Report and Feasibility Study Report

• BioTechnology Hunting, Scouting, Consultation and Evaluation

• BioTechnology Brokage, BioTechnology Transfer and Patent Licensing

• Networking of Biotechnology Transfer

TECHNOLOGY TRANSFER

• BioTechnology Integration and BioTechnology Commercialization

• Supplying high–performance Strain and research materials at Lab Scale or Industrial Scale

• Supplying Fermentation Process, Fine Chemical Synthesis Process, Extraction Process and Purification Process

• Strain Improvement, Process Optimization

ENGINEEING

• Contract Research and Contract Manufacturing

• Scale up of Process from Lab to Industry

• Basic Engineering Design, or Turn-Key Project

• Personnel Training, Erection, Commissioning and Technology Support

Technology list of APIs, Additives and Biologics for technology transfer, Welcome to contact with us, we can offer you professional service:

TECHNOLOGY, CONSULTING AND PRODUCT TRADING

ITEMS	TECH DATA	REMARKS
IMMUNOSUPPRESSIVE AGENT
他克莫司 Tacrolimus	Final Titre:600-700mg/L Fermentation time:168hrs Recovery:40%	FK506
霉酚酸 Mycophenoic acid	Final Titre:15g/L Fermentation time:264hrs Recovery:70%	Intermediate for MMF
环孢菌素 A Cyclosporin A	Final Titre: 10g/L Fermentation Time:168hrs Recovery:70%
雷帕霉素(西罗莫司) Rapamycin(Sirolimus)	Final Titre: 600-800g/L Fermentation Time:216hrs Recovery:60%	Or intermediate for Zotarolimus, Everolimus and
子囊霉素 Ascomycin	Final Titre: 500g/L Fermentation Time:216hrs Recovery:60%	FK520 Or Intermediate for Pimecrolimus
ANTIBIOTICS
阿莫西林 AMOXICILLIN	By enzyme process
万古霉素 Vancomycin	Final Titre:9-10g/L Fermentation Time: 150hrs Recovery:>70%
替考拉宁 Teicoplanin	Final Titre:4-5g/L Fermentation Time: 150hrs Recovery:>70%
达托霉素 Daptomycin	Final Titre2.0g/L Fermentation Time: 200hrs Recovery:>40%	Or cubicin
莫匹罗星 Mupirocin	Final Titre:4-5g/L Fermentation Time:60-70hrs Recovery:>75%
Pneumocandin B0	Final Titre:1.7g/L Fermentation Time: 11-12days Recovery:>60%	Caspofungin
雷莫拉宁 Ramoplanin	Final Titre:3g/L Fermentation Time: 200hrs Recovery:>60%
普那霉素（原始霉素） Pristinamycin	Final Titre:8/L Fermentation Time: 150hrs Recovery:>70%
克拉维酸（棒酸） Clavulanic acid	Final Titre:6g/L Fermentation Time:105hrs Recovery:55%
头孢菌素 C Cephalosporin C	Final Titre:40g/L Fermentation Time:168hrs Recovery:80%	各种头孢类中间体
青霉素G Penicillin G	Final Titre:120000g/L Fermentation Time:220hrs Recovery:80%
红霉素 Erythromycin	Final Titre:9-10g/L Fermentation Time:156hrs Recovery:60%	依托红霉素、琥乙红霉素、地红霉素、罗红霉素、阿奇霉素和克拉霉素的中间体
去甲金霉素 Demethylchlortetracycline (DMCT)	Final Titre:16g/L Fermentation Time:200hrs Recovery:75%	Intermediate for Minocycline, Tigecylcine
林可霉素（洁霉素） Lincomycin	Final Titre:9-10g/L Fermentation Time:200hrs Recovery:80-90%	克林霉素中间体 Clindamycin
杆菌肽 Bacitracin	Final Titre:1200U/ml Fermentation Time:50-60hrs Recovery:95%	Zinc Bacitracin for Animal feed additive
那西肽 Nosiheptide	Final Titre:1700-2000U/ml Fermentation Time:50hrs Recovery:95%	Animal feed additive
两性霉素B Amphotericin B	Final Titre:10000U/ml Fermentation Time:130-140hrs Recovery:75%
阿维拉霉素（卑霉素） Avilamycin	Final Titre:7-8g/L Fermentation Time:268hrs Recovery:95%	Animal feed additive
恩拉霉素 Enramycin	Final Titre:8-10g/L Fermentation Time:260hrs Recovery:95%	Animal feed additive
卡那霉素 Kanamycin	Final Titre:25g/L Fermentation Time:240hrs Recovery:85%
卷曲霉素 Capreomycin	Final Titre:11000U/ml Fermentation Time:150-160hrs Recovery:75%
庆大霉素C Gentamicin C	Final Titre:5-6g/L Fermentation Time:14days Recovery:75%
庆大霉素B Gentamycin B	Final Titre:1000Mmg/L Fermentation Time:120-130hrs Recovery:75%	异帕米星（Isepamicin）
多粘菌素B Polymyxin B	Final titre 2.5 g/l Fermentation time 72 hrs Recovery yield 70%
粘杆菌素 E Polymyxin E	Final titre 600000U/ml Fermentation time 96 hrs Recovery yield 75%
泰乐菌素 Tylosin	Final titre 15000 U/l Fermentation time 180 hrs Recovery yield 70%
巴龙霉素 Paromomycin	Final titre 8g/l Fermentation time170 hrs Recovery yield 70%
制霉菌素 Nystatin	Final titre 300,000IU/ml Fermentation time 280 hrs Recovery yield 85%
盐霉素 Salinomycin	Final titre 80g/l Fermentation time 268 hrs Recovery yield 90%
金霉素 Chlortetracycline	Final titre 50g/l Fermentation time 200 hrs Recovery yield 90%
四环素 Tetracycline	Final titre 40g/l Fermentation time 200 hrs Recovery yield 90%
土霉素 Oxytetracycline	Final titre 40g/l Fermentation time 200 hrs Recovery yield 90%
链霉素 Streptomycin	Final titre 28,000U/ml Fermentation time 200 hrs Recovery yield 80%
利福霉素 Rifamycin	Final titre 30g/l Fermentation time 220 hrs Recovery yield 75%
黄霉素 Flavomycin	Final titre 8g/l Fermentation time 168 hrs Recovery yield 90%
截短侧耳素 Pleuromutilin	Final titre 14000U/ml Fermentation time 300 hrs Recovery yield 80%	泰妙菌素 Tiamulin
大观霉素 Spectinomycin	Final titre 7000-10000U/ml Fermentation time 130-150 hrs Recovery yield 70%
莫能菌素 Monensin	38000u/ml Final titre 6500-8000U/ml Fermentation time 140-170 hrs Recovery yield 70-80%
妥布霉素 Tobramycin	Final titre 6500-8000U/ml Fermentation time 140-170 hrs Recovery yield 70-80%
安普霉素 Apramycin	Final titre 6500-8000U/ml Fermentation time 140-170 hrs Recovery yield 70-80%
尼可霉素 Nikkomycin	Final titre 7-8 g/l Fermentation time 70 hrs Recovery yield 80%
麦角酸 Lysergic acid	Final titre 7-8 g/l Fermentation time 360 hrs Recovery yield 70%	For cabergoline and nicergoline
夫西地酸 Fusidic Acid	Final titre 4-5 g/l Fermentation time 200 hrs Recovery yield 40%
麦迪霉素 Medimycin	Final titre 18g/l Fermentation time 200 hrs Recovery yield 75%
莫能菌素 Monensin	Final Titre:40000U/ml Fermentation Time: 300hrs Recovery:95%
马杜霉素 Maduramicin	Final Titre:612000U/ml Fermentation Time: 200hrs Recovery:95%
利福霉素 RIFAMYCIN	Final Titre:, 25g/L Fermentation Time:240hrs Recovery:80%
磷霉素 Fosfomycin
氯霉素 Chloramphenicol
灰黄霉素 Griseofulvin
螺旋霉素 , Spiramycin//Rovamycin	Final Titre:6000U/ml Fermentation Time: 160hrs Recovery:75%
小诺霉素 Micronomicin
维吉尼亚霉素 Virginmycin	R&D
亮菌甲素（假蜜环菌素） Armillarisin a.
美贝霉素 Milbemycin	Seeking
莫西菌素 Moxidectin
道拉菌素 Doramectin
土拉霉素 Tulathromvcin	Seeking
米卡芬净 micafungin	R&D
阿尼芬净 anidulafungin	R&D

Bio-PESTICIDE
阿维菌素 Abamectin	Final Titre:4.5g/l Flask:4.8-5.0g/L Time:240hrs Recovery:80%	Including its derivatives
多杀菌素 Spinosad	Final Titre:12g/L Fermentation Time:200-240hrs Recovery:80%	Bio-pesticide
井冈霉素 Validamycin	Final Titre: 3-4g/L Fermentation Time:60-70hrs Recovery:80%
春雷霉素 Kasugamycin	Final Titre: 8000-1000U/ml Fermentation Time:192hrs Recovery80%
多抗霉素 Polyoxin	Final Titre: 5000U/ml Fermentation Time:192hrs Recovery：80%
脱落酸 Abscisic Acid (ABA)	Final Titre:1.6g/L Fermentation Time:70-72hrs Recovery:60-65%	Plant hormone Biopesticide
赤霉素 Gibberellin (GA3)	Final Titre:2.5-2.8g/L Fermentation Time:150-160hrs Recovery:80%
中生霉素 zhongshengmycin	Final Titre:10g/L Fermentation Time:1200hrs Recovery:80%
枯草芽孢杆菌 Bacillus subtilis	Final Titre6000U/ml Fermentation Time:150-160hrs Recovery:80%
苏云金杆菌 Bacillus thuringiensis	Final Titre:5500g/ml Fermentation Time:150-160hrs Recovery:80%
浏阳霉素 Liuyangmycin
宁南霉素 Ningnanmycin
链霉素 streptomycin		For agriculture
ANTI-DIABETES
米格列醇 Miglitol	Final Titre:2g/L Fermentation Time:70-72hrs Recovery:60-65% Synthesis:90%
阿卡波糖 Acarbose	Final Titre:5-6g/L Fermentation T, ime:130-150hrs Recovery:30-40%
伏格列波糖 Veglibose	Chemical synthesis

ANTI-TUMOR
柔红霉素 Daunomycin	Final Titre:1.5g/L Fermentation Time:168hrs Recovery:>67%	For epirubicin, Idarubicin, doxorubicin
洋红霉素 Carminomycin	Final titre 0.15 g/l Fermentation time 168 hrs Recovery yield 65%
偏端霉素 Distamycin	Final titre 2g/l Fermentation time 120 hrs Recovery yield 52%
博莱霉素 Bleomycin	Final titre 4g/l Fermentation time 168 hrs Recovery yield 70%
紫杉醇 Paclitaxel	Final titre 200mg/l Fermentation time 120 hrs Recovery yield 50%
丝裂霉素C Mitomycin C	Final titre 1000mg/l Fermentation time 200 hrs Recovery yield 50%
阿霉素 Doxorubicin	Chemical synthesis	Or fermentation
棕霉素 Bruneomycin	Final titre 150mg/l Fermentation time 144 hrs Recovery yield 60%
放线菌素D Dactinomycin D	Chemical synthesis
表阿霉素 Epirubicin	Chemical synthesis
伊达比星 Idarubicin	Chemical synthesis
吡柔比星 Pirarubicin	Chemical synthesis

ANTI-CARDIVASCULAR
洛伐他汀 Lovastatin	Final Titre:16g/L Fermentation Time:168hrs Recovery:70%
美伐他汀 Compactin	Final Titre:10g/L Fermentation Time:200-220hrs
普伐他汀 Pravastatin	Final Titre: 8.0g/l Conversion rate:70% Cycle time: 120-144
阿托伐他汀 Atorvastatin	Chemical synthesis
瑞舒伐他汀 Rosuvastatin	Chemical synthesis
辛伐他汀 Simvastatin	Chemical synthesis
氟伐他汀 Fluvastatin	Chemical synthesis

ORGANNIC ACID		Biobased chemicals
衣康酸 Itaconic Acid	Acid:>6% Cycle time:40-50hrs Conversion:>50% Fermentation data:1.4g/L/hr	The product gets to Pfizer
柠檬酸 Citric acid
莽草酸 Shikimic Acid	Titre: 25g/L
L-乳酸 L-Lactic acid	Acid:16-18% Conversion rate; 90%
丙酮酸 Pyruvic acid	Titre:55-65g/L Conversion rate:55-60% Fermentation time:60hr Recovery:70%
长链二元酸 Long-chain dicarbxylic acid	DCA13-18: 180g/L, Fermentation time:5-6days

Bio-based products
1，3-丙二醇 1,3-propandiol(PDO)	Titre: 85g/L Conversion rate:60% Productivity:1.2-1.4g/LH	Chemical
2，3-丁二醇 2,3-butandiol	50-65g/L	By product from PDO
丁醇 Butanol	20g/L
甘油 Glycerol	Titre:160g/l Time:78hrs Productivity:2g/LH Mass conversion rate: 48.6%	Chemical
丙烯酰胺 Acrylamide	Enzyme activity: 1 0g/ml Acrylonitrile consumption: 0.75t/t Conversion rate: 99.9%	Chemical
烟酰胺 Nicotinamide	Enzyme activity: 8g/ml Nicotinonitrile consumption: 0.85t/t Conversion rate: 99.999% Assay: 100%	Chemical
羟基乙酸 Hydroxyacetic acid	Enzyme activity: 0.1g/ml Glycolonitrile consumption: 0.78t/t Conversion rate: 99.9% Assay: 99.5% ( pharma grade)	Chemical
黄原胶 Xanthan	Final Titre:5-6g/L Fermentation Time:36hrs Recovery:80%
琥珀酸（丁二酸） Succinic acid
苹果酸 Malic acid
牛磺酸 Taurine
乙酸（醋酸） Acetic acid
聚羟基脂肪酸 Polyhydroxyalkanoates (PHAs)		degradable plastics
聚乳酸 Polylactic acid, PLA

VITAMIN AND CAROTENOID
维生素B2 Vitamin B2	Final titre 30g/l Fermentation time 72 hrs Recovery yield 80%
维生素B12 Vitamin B12	Final titre 250mg/l TIME:180hrs
维生素C Vitamin C	Final titre 11-12g/l Fermentation time 60 hrs Conversion rate; 90%
番茄红素 Lycopene	Final Titre:>1.0g/L
胡萝卜素 Beta Carotene	Final Titre:2.5-3.0g/L Fermentation Time:72hrs Recovery:75-80%
虾青素 Astaxanthin	Final Titre:2g/L
维生素D2 Vitamin D2	Light reaction
维生素D3 Vitamin D3	Light reaction
维生素A Vitamin A	chemical synthesis
维生素H Vitamin H	By fermentation Or chemical synthesis	Biotin
HORMONE		Biotransformation
Hormone
雄烯二酮 Anostenedione(AD)	Final titre 15 g/l Fermentation time 200 hrs Recovery yield 75%	Intermediate
雄二烯二酮 androsta-1,4-diene-3,17-dione (ADD)	Final titre 10 g/l Fermentation time 200 hrs Recovery yield 72%	Intermediate
泼尼松龙 Prednisolone	Finaltitre>20g/L(Maximum 70g/L) time：5-8 hrs conversion: 97～100％
睾丸素 Testosterone	Final Titre 5g/L
去氢甲睾酮 Methandrostenolone	Final Titre 10g/L
Pregna 1,4,9,17 acetate	Final Titre 5g/L
Pregna 1,2,9,21	Final Titre 5g/L
螺内酯 SPIRONOLACTONE
依普利酮 Eplerenone
ANTISPETIC
异抗血酸 D-isoascorbate	Productivity:18-20g/L
那他霉素 Natamycin	Final Titre:8-10g/L Fermentation Time:140-150hrs	antiseptic
乳酸链球菌素 Nisin		Natural antiseptic

HEALTHCARE
谷胱甘肽 Glutathione(GSH)	Titre: 5g/L Biomass:140g/L Fermentation time 72 hrs Recovery yield 45%
辅酶Q10 Coenzyme Q10	Final titre2.5-3.0 g/l Fermentation time 96 hrs Recovery yield 60%
透明质酸 Hyaluronic acid (HA)	Final Titre:6-7g/L Fermentation Time:20hrs Recovery:90%	Best performance is 10g/L
花生四烯酸 Arachidonic acid (AA)	Final titre 9+1.5 g/l Fermentation time 192hrs Recovery yield: 65%	Food additives Healthcare
S-腺苷甲硫氨酸 S-adenosylmethionine (SAMe)
二十二碳六烯酸 Docosahexaenic Acid(DHA)

Others
普鲁兰 Pullulan	Titre:60-70g/L Conversion:60-70%
灵芝多糖 Polysaccharide	Final Titre: 1.5g/l	Cordyceps.sinensis
赤藓糖醇 Erythritol		excipient
Instant Active Yeast		Food processing
Yeast extract		Food savor
麦角固醇 Ergosterol		For Vitamin D
Alpha-cyclodextrin		excipient
Beta- cyclodextrin		excipient
肌苷 Inosine	Productivity ：100g/L time： 90小时 conversion 35% recovery： 90%
鸟苷 Guanosine	Titre :50-60g/L. time:72小时 conversion: 25% recovery: 90%
WEIGHT LOSING
尼波司他汀 Lipstatin	Final Titre:8-10g/L Fermentation Time:168hrs Recovery:75% Conversion:77.8%	Orlistat（奥利司他） Weight losing

Enzymes		酶制剂
Phytase	20000U/ml
Xylase	Inquiry
Celluase	Inquiry
Amylase	Inquiry
Protease	Inquiry
Acylase,	Inquiry
Many other,Etc	Inquiry
Penicillin G amidase

Amino acids	Folder & food additives	Medicine, Healthcare
色氨酸 L-Tryptophan	Final titer 25-30 g/l
苯丙氨酸 L-Phenylalanine	Final titer 40 +/- 2 g/l
苏氨酸 L-Threonine	Final titer 120 g/l
精氨酸 L-Arginine	Final titre > 60 g/l
缬氨酸 L-Valine	Final titre 52 +/- 2 g/l
赖氨酸 L-Lysine	Final titre 160 +/- 10 g/l
亮氨酸 L-Leucine，	Final Titre:40g/L Fermentation Time: 65hrs Recovery:70% Conversion:20%
异亮氨酸 L-isoleucine	Final Titre:30g/L Fermentation Time: 25hrs Recovery:80%
谷氨酰胺 L-Glutamine	Final Titre:80g/L Fermentation Time: 65hrs Recovery:75%
谷氨酸 Glutmate	productivity：180-200g/L. time：36hrs conversion rate：70% recovery ：95%

, 6>

Final Titre: 8000-1000U/ml

Fermentation Time:192hrs

Recovery80%

多抗霉素

Polyoxin

Final Titre: 5000U/ml

Fermentation Time:192hrs

Recovery：80%

脱落酸

Abscisic Acid (ABA)

Final Titre:1.6g/L

Fermentation Time:70-72hrs

Recovery:60-65%

Plant hormone

Biopesticide

赤霉素

Gibberellin (GA3)

Final Titre:2.5-2.8g/L

Fermentation Time:150-160hrs

Recovery:80%

中生霉素

zhongshengmycin

Final Titre:10g/L

Fermentation Time:1200hrs

Recovery:80%

枯草芽孢杆菌

Bacillus subtilis

Final Titre6000U/ml

Fermentation Time:150-160hrs

Recovery:80%

苏云金杆菌

Bacillus thuringiensis

Final Titre:5500g/ml

Fermentation Time:150-160hrs

Recovery:80%

浏阳霉素

Liuyangmycin

宁南霉素

Ningnanmycin

链霉素

streptomycin

&n, bsp;

For agriculture

ANTI-DIABETES

米格列醇

Miglitol

Final Titre:2g/L

Fermentation Time:70-72hrs

Recovery:60-65%

Synthesis:90%

阿卡波糖

Acarbose

Final Titre:5-6g/L

Fermentation T, ime:130-150hrs

Recovery:30-40%

伏格列波糖

Veglibose

Chemical synthesis

ANTI-TUMOR

柔红霉素

Daunomycin

Final Titre:1.5g/L

Fermentation Time:168hrs

Recovery:>67%

For epirubicin,

Idarubicin,

doxorubicin

洋红霉素

Carminomycin

Final titre 0.15 g/l

Fermentation time 168 hrs

Recovery yield 65%

偏端霉素

Distamycin

Final titre 2g/l

Fermentation time 120 hrs

Recovery yield 52%

博莱霉素

Bleomycin

Final titre 4g/l

Fermentation time 168 hrs

Recovery yield 70%

紫杉醇

Paclitaxel

Final titre 200mg/l

Fermentation time 120 hrs

Recovery yield 50%

丝裂霉素C

Mitomycin C

Final titre 1000mg/l

Fermentation time 200 hrs

Recovery yield 50%

阿霉素

Doxorubicin

Chemical synthesis

Or fermentation

棕霉素

Bruneomycin

Final titre 150mg/l

Fermentation time 144 hrs

Recovery yield 60%

放线菌素D

Dactinomycin D

Chemical synthesis

表阿霉素

Epirubicin

Chemical synthesis

伊达比星

Idarubicin

Chemical synthesis

吡柔比星

Pirarubicin

Chemical synthesis

ANTI-CARDIVASCULAR

洛伐他汀

Lovastatin

Final Titre:16g/L

Fermentation Time:168hrs

Recovery:70%

美伐他汀

Compactin

Final Titre:10g/L

Fermentation Time:200-220hrs

普伐他汀

Pravastatin

Final Titre: 8.0g/l

Conversion rate:70%

Cycle time: 120-144

阿托伐他汀

Atorvastatin

Chemical synthesis

瑞舒伐他汀

Rosuvastatin

Chemical synthesis

辛伐他汀

Simvastatin

Chemical synthesis

氟伐他汀

Fluvastatin

Chemical synthesis

ORGANNIC ACID

Biobased chemicals

衣康酸

Itaconic Acid

Acid:>6%

Cycle time:40-50hrs

Conversion:>50%

Fermentation data:1.4g/L/hr

The product gets to Pfizer

柠檬酸

Citric acid

莽草酸

Shikimic Acid

Titre: 25g/L

L-乳酸

L-Lactic acid

Acid:16-18%

Conversion rate; 90%

丙酮酸

Pyruvic acid

Titre:55-65g/L

Conversion rate:55-60%

Fermentation time:60hr

Recovery:70%

长链二元酸

Long-chain dicarbxylic acid

DCA13-18: 180g/L,

Fermentation time:5-6days

Bio-based products

1，3-丙二醇

1,3-propandiol(PDO)

Titre: 85g/L

Conversion rate:60%

Productivity:1.2-1.4g/LH

Chemical

2，3-丁二醇

2,3-butandiol

50-65g/L

By product from PDO

丁醇

Butanol

20g/L

甘油

Glycerol

Titre:160g/l

Time:78hrs

Productivity:2g/LH

Mass conversion rate: 48.6%

Chemical

丙烯酰胺

Acrylamide

Enzyme activity: 1 0g/ml

Acrylonitrile consumption: 0.75t/t

Conversion rate: 99.9%

Chemical

烟酰胺

Nicotinamide

Enzyme activity: 8g/ml

Nicotinonitrile consumption: 0.85t/t

Conversion rate: 99.999%

Assay: 100%

Chemical

羟基乙酸

Hydroxyacetic acid

Enzyme activity: 0.1g/ml

Glycolonitrile consumption: 0.78t/t

Conversion rate: 99.9%

Assay: 99.5% ( pharma grade)

Chemical

黄原胶

Xanthan

Final Titre:5-6g/L

Fermentation Time:36hrs

Recovery:80%

琥珀酸（丁二酸）

Succinic acid

苹果酸

Malic acid

牛磺酸

Taurine

乙酸（醋酸）

Acetic acid

聚羟基脂肪酸

Polyhydroxyalkanoates (PHAs)

degradable plastics

聚乳酸

Polylactic acid, PLA

VITAMIN AND CAROTENOID

维生素B2

Vitamin B2

Final titre 30g/l

Fermentation time 72 hrs

Recovery yield 80%

维生素B12

Vitamin B12

Final titre 250mg/l

TIME:180hrs

维生素C

Vitamin C

Final titre 11-12g/l

Fermentation time 60 hrs

Conversion rate; 90%

番茄红素

Lycopene

Final Titre:>1.0g/L

胡萝卜素

Beta Carotene

Final Titre:2.5-3.0g/L

Fermentation Time:72hrs

Recovery:75-80%

虾青素

Astaxanthin

Final Titre:2g/L

维生素D2

Vitamin D2

Light reaction

维生素D3

Vitamin D3

Light reaction

维生素A

Vitamin A

chemical synthesis

维生素H

Vitamin H

By fermentation

Or chemical synthesis

Biotin

HORMONE

Biotransformation

Hormone

雄烯二酮

Anostenedione(AD)

Final titre 15 g/l

Fermentation time 200 hrs

Recovery yield 75%

Intermediate

雄二烯二酮

androsta-1,4-diene-3,17-dione

(ADD)

Final titre 10 g/l

Fermentation time 200 hrs

Recovery yield 72%

Intermediate

泼尼松龙

Prednisolone

Finaltitre>20g/L(Maximum 70g/L)

time：5-8 hrs

conversion: 97～100％

睾丸素

Testosterone

Final Titre 5g/L

去氢甲睾酮

Methandrostenolone

Final Titre 10g/L

Pregna 1,4,9,17 acetate

Final Titre 5g/L

Pregna 1,2,9,21

Final Titre 5g/L

螺内酯

SPIRONOLACTONE

依普利酮

Eplerenone

ANTISPETIC

异抗血酸

D-isoascorbate

Productivity:18-20g/L

那他霉素

Natamycin

Final Titre:8-10g/L

Fermentation Time:140-150hrs

antiseptic

乳酸链球菌素

Nisin

Natural antiseptic

HEALTHCARE

谷胱甘肽

Glutathione(GSH)

Titre: 5g/L

Biomass:140g/L

Fermentation time 72 hrs

Recovery yield 45%

辅酶Q10

Coenzyme Q10

Final titre2.5-3.0 g/l

Fermentation time 96 hrs

Recovery yield 60%

透明质酸

Hyaluronic acid (HA)

Final Titre:6-7g/L

Fermentation Time:20hrs

Recovery:90%

Best performance is 10g/L

花生四烯酸

Arachidonic acid (AA)

Final titre 9+1.5 g/l

Fermentation time 192hrs

Recovery yield: 65%,

Food additives

Healthcare

S-腺苷甲硫氨酸

S-adenosylmethionine (SAMe)

二十二碳六烯酸

Docosahexaenic Acid(DHA)

Others

普鲁兰

Pullulan

Titre:60-70g/L

Conversion:60-70%

灵芝多糖

Polysaccharide

Final Titre: 1.5g/l

Cordyceps.sinensis

赤藓糖醇

Erythritol

excipient

Instant Active Yeast

Food processing

Yeast extract

Food savor

麦角固醇

Ergosterol

For Vitamin D

Alpha-cyclodextrin

excipient

Beta- cyclodextrin

excipient

肌苷

Inosine

Productivity ：100g/L
time： 90小时
conversion 35%
recovery： 90%

鸟苷

Guanosine

Titre :50-60g/L.
time:72小时
conversion: 25%
recovery: 90%

WEIGHT LOSING

尼波司他汀

Lipstatin

Final Titre:8-10g/L

Fermentation Time:168hrs

Recovery:75%

Conversion:77.8%

Orlistat（奥利司他）

Weight losing

Enzymes

酶制剂

Phytase

20000U/ml

Xylase

Inquiry

Celluase

Inquiry

Amylase

Inquiry

Protease

Inquiry

Acylase,

Inquiry

Many other,Etc

Inquiry

Penicillin G amidase

Amino acids

Folder & food additives

Medicine, Healthcare

色氨酸

L-Tryptophan

Final titer 25-30 g/l

苯丙氨酸

L-Phenylalanine

Final titer 40 +/- 2 g/l

苏氨酸

L-Threonine

Final titer 120 g/l

精氨酸

L-Arginine

Final titre > 60 g/l

缬氨酸

L-Valine

Final titre 52 +/- 2 g/l

赖氨酸

L-Lysine

Final titre 160 +/- 10 g/l

亮氨酸

L-Leucine，

Final Titre:40g/L

Fermentation Time: 65hrs

Recovery:70%

Conversion:20%

异亮氨酸

L-isoleucine

Final Titre:30g/L

Fermentation Time: 25hrs

Recovery:80%

谷氨酰胺

L-Glutamine

Final Titre:80g/L

Fermentation Time: 65hrs

Recovery:75%

谷氨酸

Glutmate

productivity：180-200g/L.
time：36hrs
conversion rate：70%
recovery ：9, 5%

发表时间：2009-4-29