雷帕霉素(Rapamycin),又名西罗莫司(Sirolimus)是新型大环内酯的抗排斥药物,是目前世界上最新的强效免疫抑制剂,临床上用于器官移植的抗排斥反应和自身免疫性疾病的治疗。它的免疫抑制活性比现行临床广泛使用的环孢素强数十倍,毒性低,用量小(2mg/天/人),且与环孢素有协同免疫抑制作用,临床上与环孢素联合使用。与环孢素和FK506(他克莫司)相比,西罗莫司是肾毒性最低的免疫抑制剂,且无神经毒性。美国已在全球80个中心进行1295例肾移植试验,效果显著,副作用极小。
Chemical Name
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]-oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
MOL.FORMULA: C51H79NO13
M.W.: 914.17
CAS: 53123-88-9
Pharmacology:
Immunosuppressant
Specifications:
Assay 98.0%
Packaging:
1kg/aluminium can, Higher quantities: depends on customer request