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| 【主 题】 ： |
In Vivo PK |
| 【联系人名】 ： |
Shirley |
| 【电子邮件】 ： |
contact@creative-animodel.com |
| 【联系电话】 ： |
16316269181 |
| 【发布日期】 ： |
2015-1-26 |
| 【详细说明】 ： |
Translational Research (PK) will be involved in the design and execution of in vivo PK/ADME studies and the evaluation of clinical pharmacokinetic data to support the development of Creative Animodel product candidates.
Creative Animodel conducts typical PK study which involves administering a fixed amount of the drug (the dose) to the subject (various animals) and at various times post dose, samples of an easily accessible tissue (usually blood/plasma) are drawn and collected for analysis of the drug and its metabolite concentrations.
Duties and responsibilities will include：
• Evaluating compounds in various formulations, both solution as well as suspension dosing in various species.
• Studying correlative aspects between the in vitro and in vivo metabolism of analogs to increase throughput and help lower cost.
• Dose escalation studies in rats or dogs with the potential for follow up in the 7- and 28-day tox studies in rats/dogs that would help plan for Phase I and in some cases Phase II clinical trials.
• Cassette (n-in-1) PK for early discovery compound screening and decision prioritization
• Drug distribution in tissue/organ and body fluid and determination of blood and brain ratio for brain penetration
• Metabolic kinetics with active metabolites
• PK analysis using WinNonlin
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English
