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| 【主 题】 ： |
Human Urothelial Cells (HUC) |
| 【联系人名】 ： |
Wendy |
| 【电子邮件】 ： |
contact@creative-bioarray.com |
| 【联系电话】 ： |
1-631-626-9181 |
| 【发布日期】 ： |
2015-1-26 |
| 【详细说明】 ： |
The urothelial cells, the cells lining the surface
of the urinary bladder, are comprised of a unique
cell type with high plasticity and a variety of cell
functions. They are the first line of bladder
defense and serve as an interface between pathogens
that is equipped with several defense mechanisms to
prevent adherence of pathogens and maintain
impermeability to urinary solutes. The urothelial
cells express both estrogen receptor-alpha and beta
, epidermal growth factor receptor and fibroblast
growth factor receptor ; these receptors play a
major role on urothelial cell response to injury and
infection. They also release a number of cytokines
and other immune system mediators and this newly
recognized immunoregulatory potential of the
urothelial cell warrants further investigation
through the application of two recent developments:
1) the ability to culture normal urothelial cells in
the laboratory and 2) the understanding of how
immunoregulatory communications are generated for
the biological functions of urothelial cells through
signal transduction pathways.HUC from Bioarray
Research Laboratories are isolated from the human
bladder. HUC are cryopreserved at passage one and
delivered frozen. Each vial contains >5 x 10^5 cells
in 1 ml volume. HUC are characterized by
immunofluorescent method with antibodies to
cytokeratin-18, -19 and vimentin. HUC are negative
for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and
fungi. HUC are guaranteed to further expand for 15
population doublings in the condition provided by
Bioarray Research Laboratories.
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English
