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| 【主 题】 ： |
Recombinant Mouse Cystatin C, His-tagged |
| 【联系人名】 ： |
Candy Ton |
| 【电子邮件】 ： |
yuanyuanton@gmail.com |
| 【联系电话】 ： |
1-631-5599269 |
| 【发布日期】 ： |
2015-1-26 |
| 【详细说明】 ： |
Product Overview
Recombinant Mouse CST3 produced in human cells encoding the mouse CST3 precursor (Met 1- Ala 140 ) was expressed with a C-terminal his tag.
Description
Mouse Cystatin-C, also known as Cystatin-3, Neuroendocrine basic polypeptide, Post-gamma-globulin, and CST3, is a secreted type 2 cysteine proteinase inhibitors of the cystatin superfamily, and exerts actions on a variety of cysteine proteases including papain and Cathepsins B, H, K, L and S. As the most abundant extracellular inhibitor of cysteine proteases, Cystatin-C encoded by a housekeeping gene is found ubiquitously in all organs and biological fluids at high concentration levels. It has been shown that Cystatin-C binds amyloid-beta and reduces cerebral amyloid-beta deposition or inhibits its fibril formation in an APP-transgenic mouse model. Thus, a point mutation in this gene (Leu 68 to Gln) hsa been associated with a severe hereditary form of amyloid angiopathy. Studies have also investigated Cystatin-C as a marker of kidney function and thyroid dysfunction prior to creatinine, and could be a useful clinical tool to identify HIV-infected persons. In addition, Cystatin-C expression is up-regulated in malignance of certain tumor progression.
Source
Human Cells.
Purity
> 95 % as determined by SDS-PAGE.
Formulation
Supplied as a 0.2μm filtered solution of 20mM HEPES, 150mM NaCl, pH 7.0.
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method. |
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English
