|
|
|
| 【主 题】 ： |
Recombinant Human Cystatin E/M, His-tagged |
| 【联系人名】 ： |
Candy Ton |
| 【电子邮件】 ： |
yuanyuanton@gmail.com |
| 【联系电话】 ： |
1-631-5599269 |
| 【发布日期】 ： |
2015-1-26 |
| 【详细说明】 ： |
Description
Cystatin E/M, also referred to as CST6, is a member of type 2 cysteine proteinase inhibitors of the cystatin superfamily, and inhibits papain and cathepsin B. Cystatin E is a low molecular mass secreted protein existing in both a glycosylated (17 kDa) and an unglycosylated (14 kDa) form, with two characteristic intrachain disulfide bridges. Expression of cystatin M/E is found to be restricted to the epidermis, more specifically in the stratum granulosum, sweat glands, sebaceous glands, and the hair follicles. In addition to its function as a cysteine protease inhibitor, cystatin M/E also serves as a target for cross-linking by transglutaminases. Accordingly, cystatin M/E was suggested to be involved in barrier formation and maintenance. Furthermore, studies have revealed that cystatin M/E is frequently epigenetically inactivated during breast carcinogenesis, and thus be regarded as a candidate of tumour suppressor gene.
Source
Human Cells.
Purity
> 95% as determined by SDS-PAGE.
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Predicted N Terminal
Arg 29.
Formulation
Lyophilized from sterile 25 mM MES, 0.15M NaCl , pH 6.5.
Stability
Samples are stable for up to twelve months from date of receipt at -70℃. |
|
|
|
|
English
