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| 【主 题】 ： |
Recombinant Human Cystatin D, His-tagged |
| 【联系人名】 ： |
Candy Ton |
| 【电子邮件】 ： |
yuanyuanton@gmail.com |
| 【联系电话】 ： |
1-631-5599269 |
| 【发布日期】 ： |
2015-1-26 |
| 【详细说明】 ： |
Product Overview
Recombinant Human cystatin D was encoding the pro form of human Cystatin D (NP_001891.2) (Met1-Val142) produced in HEK293. It was expressed with a C-terminal his tag.
Description
Cystatins are natural inhibitors of papain-like (family C1) and legumain-related (family C13) cysteine peptidases. The mammalian cystatin superfamily members are of three major types, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. As a member of type 2 cystatin, cystatin D is a single-domain protein and also has cysteine residues that form disulfide bridges. In contrast with the wider distribution of all the other family 2 cystatins, cystatin D is tissue-restricted expressed and has been found only in saliva and tears. And meanwhile, it displays an inhibition profile with a preferential inhibition on cathepsin S, H, L. Although the exact functions are largely unknown, it has reported that cystatin D is involved in the inhibition of virus replication and apoptosis.
Molecular Mass
The secreted mature recombinant human CST5 comprises 133 amino acids with the predicted molecular mass of 15.2kDa as estimated by SDS-PAGE under reducing conditions.
Source
Human Cells (HEK293).
Predicted N Terminal
Gly 21.
Endotoxin
<1.0EU per 1μg cytokine as determined by the LAL method. |
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English
