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| 【主 题】 ： |
Recombinant Human Cystatin F |
| 【联系人名】 ： |
Candy Ton |
| 【电子邮件】 ： |
yuanyuanton@gmail.com |
| 【联系电话】 ： |
1-631-5599269 |
| 【发布日期】 ： |
2015-1-26 |
| 【详细说明】 ： |
Product Overview
Recombinant Human cystatin F was produced in HEK293. The mature form of the human Cystatin F (NP_003641.2) (Met1-His145) was obtained after cleavage of the C-terminal human IgG1 Fc region from the purified chimeric protein.
Description
The cystatin superfamily members are important natural cysteine protease inhibitors present in a wide variety of organisms and are divided into three classes. Cystatin F, also known as leukocystatin and CMAP (Cystatin-like Metastasis-Associated Protein), is a type 2 cystatin and its expression is limited to hematopoietic cells, with the highest expression levels being observed in monocytes, dendritic cells, and certain types of T-cells. Furthermore, cystatin F mRNA becomes up-regulated during dendritic cell maturation, and thus suggests a specific role of cystatin F in immune regulation. Cystatin F is produced as a dimer, an inactive cathepsin inhibitor which is activated by chemical reduction. In addition, Cystatin F and its homologues have been observed expressing in various human cancer cell lines established from malignant tumors, and thus indicates a new diagnosis and prevention approach of certain human carcinomas metastasis.
Molecular Mass
The recombinant human Cystatin F consists of 132 amino acids and predicts a molecular mass of 15.2KDa. As a result of glycosylation, the apparent molecular mass of rhCystatin F is approximately 25kDa in SDS-PAGE.
Source
Human Cells (HEK293).
Predicted N Terminal
Gly 20. |
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English
