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| 【主 题】 ： |
Recombinant Mouse Cystatin B, His-tagged |
| 【联系人名】 ： |
Candy Ton |
| 【电子邮件】 ： |
yuanyuanton@gmail.com |
| 【联系电话】 ： |
1-631-5599269 |
| 【发布日期】 ： |
2015-1-26 |
| 【详细说明】 ： |
Product Overview
A DNA sequence encoding the mouse CTSB ( P10605 ) ( Met 1 - Phe 339 ) was fused with a polyhistidine tag at the C-terminus.
Description
Mouse cystatin-B, also known as CPI-B, Liver thiol proteinase inhibitor, Stefin-B, CSTB and CST6, is a cytoplasm and nucleus protein which belongs to the cystatin family. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the proteases leaking from lysosomes. Defects in Cystatin-B / CSTB are the cause of progressive myoclonic epilepsy type 1 (EPM1) which is an autosomal recessive disorder characterized by severe, stimulus-sensitive myoclonus and tonic-clonic seizures.
Source
Mouse
Host
Human Cells
Form
Lyophilized from sterile PBS , pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.
Purity
> 95 % as determined by SDS-PAGE
Bio-activity
Measured by its ability to cleave the fluorogenic peptide substrate Z-LR-AMC ( R&D Systems, Catalog # ES008 ). The specific activity is > 1,000 pmoles / min / µg |
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English
