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| 【主 题】 ： |
Recombinant Human Connective Tissue Growth Factor, His-tagged |
| 【联系人名】 ： |
Candy Ton |
| 【电子邮件】 ： |
yuanyuanton@gmail.com |
| 【联系电话】 ： |
1-631-5599269 |
| 【发布日期】 ： |
2015-1-26 |
| 【详细说明】 ： |
Product Overview
The Connective Tissue Growth Factor His-Tagged Fusion Protein, produced in E. coli, is 38.3 kDa protein containing 323 amino acid residues of the CTGF human and 23 additional amino acid residues – His Tag, Xa - cleavage site (underlined).
Description
Connective Tissue Growth Factor belongs to the CCN family of proteins. The CCN family presently consists of six members in human also known as: Cyr61 (Cystein rich 61), CTGF (Connective Tissue Growth Factor), Nov (Nephroblastoma Overexpressed gene), WISP-1, 2 and 3 (Wnt-1 Induced Secreted Proteins). The CCN genes encode secreted proteins associated with the Extracellular Matrix (ECM) and cell membrane. CCN proteins are matricellular proteins which are involved in the regulation of various cellular functions including: proliferation, differentiation, survival, adhesion and migration. They are expressed in derivatives of the three embryonic sheets and are implicated in the development of kidney, nervous system, muscle, bone marrow, cartilage and bone. During adulthood, they are implicated in wound healing, bone fracture repair, and pathologies such as: fibrosis, vascular ailments and tumorigenesis. Full length secreted CCN proteins can show an antiproliferative activity, whereas truncated isoforms are likely to stimulate proliferation and behave as oncogenes.
Source
Escherichia Coli. |
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English
