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| 【主 题】 ： |
Recombinant Mouse Ctla4, His-tagged |
| 【联系人名】 ： |
Candy Ton |
| 【电子邮件】 ： |
yuanyuanton@gmail.com |
| 【联系电话】 ： |
1-631-5599269 |
| 【发布日期】 ： |
2015-1-26 |
| 【详细说明】 ： |
Product Overview
Recombinant Mouse Ctla4 protein (Met 1 - Phe 162), fused with the His tag at the C-terminus, was expressed in Human Cells.
Description
Mouse cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is widely expressed with highest levels in lymphoid tissues. CTLA4 contains a extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants encoding different isoforms have been characterized. CTLA4 is similar to the T-cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions.
Source
Human Cells.
Molecular Mass
The recombinant mouse CTLA4 consists of 138 amino acids and has a predicted molecular mass of 15.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm CTLA4 is approximately 25-30 kDa due to glycosylation.
Predicted N Terminal
Glu 36.
Purity
> 98% as determined by SDS-PAGE.
Formulation
Lyophilized from sterile PBS, pH 7.4.
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Storage And Stability
Samples are stable for up to twelve months from date of receipt at -700C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
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