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| 【主 题】 ： |
Recombinant Human Cytotoxic T-lymphocyte-associated Protein 4, Fc-His |
| 【联系人名】 ： |
Candy Ton |
| 【电子邮件】 ： |
yuanyuanton@gmail.com |
| 【联系电话】 ： |
1-631-5599269 |
| 【发布日期】 ： |
2015-1-26 |
| 【详细说明】 ： |
Product Overview
Recombinant human CTLA4 produced in human cells encoding the CTLA4 extracellular domain (Met 1-Phe 162) was fused with the C-terminal his-tagged Fc region of human IgG1 at the C-terminus.
Description
Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is widely expressed with highest levels in lymphoid tissues. CTLA4 contains a extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants encoding different isoforms have been characterized. CTLA4 is similar to the T-cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus (SLE), Graves disease (GRD), Celiac disease type 3 (CELIAC3) and Hepatitis B virus infection (HBV infection).
Source
Human Cells.
Formulation
Supplied as a 0.2μm filtered solution of PBS, pH7.4.
Purity
> 92 % as determined by SDS-PAGE.
Endotoxin
< 1.0 EU per 1μg of the protein as determined by the LAL method. |
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English
