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| 【主 题】 ： |
Recombinant Mouse Cathepsin D, His-tagged |
| 【联系人名】 ： |
Candy Ton |
| 【电子邮件】 ： |
yuanyuanton@gmail.com |
| 【联系电话】 ： |
1-631-5599269 |
| 【发布日期】 ： |
2015-1-26 |
| 【详细说明】 ： |
Product Overview
Recombinant Mouse Cathepsin D encoding the mouse CTSD (NP_034113.1) precursor (Met 1- Leu 410) was expressed with a His tag at the C-terminus. It was produced in Human Cells (HEK293).
Description
Cathepsin D (CTSD) is a well known lysosomal aspartyl protease and is a member of the peptidase C1 family found in almost all cells and tissues of mammals. It has a specificity similar to but narrower than that of pepsin A. Cathepsin D plays an important role in the degradation of proteins, the generation of bioactive proteins, antigen processing, etc. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis, and can also induce apoptosis in presence of cytotoxic factors. However, on contrast, in certain studies an inhibitory role of CTSD in apoptosis was also reviewed. In addition, CTSD secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis, suggesting its contribution to the prevention of tumor growth and angiogenesis-dependent growth of metastases.
Molecular Mass
The secreted recombinant mouse CTSD pro form consists of 401 amino acids and has a predicted molecular mass of 44.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmCTSD is approximately 48 kDa due to glycosylation.
Source
Human Cells (HEK293). |
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English
