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| 【主 题】 ： |
Reboxetine mesylate |
| 【联系人名】 ： |
Linna Green |
| 【电子邮件】 ： |
account@bocsci.com |
| 【联系电话】 ： |
15166698109 |
| 【发布日期】 ： |
2016-9-6 |
| 【详细说明】 ： |
Reboxetine mesylate is a potent and selective
inhibitor of noradrenalin uptake (K i values are
1.1, 129 and > 10000 nM for rat NET, SERT and DAT
respectively). Displays > 1000-fold selectivity over
α -adrenoceptors, 5-HT, dopamine and muscarinic ACh
receptors.
Norepinephrine: IC50 = 8.2 nM; 5-HT: IC50 = 1.07 μM;
H1: IC50 = 1.4 μM; α1 Adrenergic: IC50 = 10 μM
NET: Ki= 1.1 nM (rat); Norepinephrine reuptake: Ki=
8.2 nM; [3H]-dopamine uptake to the human
norepinephrine transporters: Ki= 11 nM (Madin–Darby
canine kidney cells); SERT: Ki= 129 nM (rat); DAT:
Ki>10 μM (rat) |
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